Evolution of the human proteome
نویسندگان
چکیده
We propose the sequencing of 9 chordate species to complete the coverage of all major nodes of chordate evolution with at least two sequenced species. These include; 1. Reptile 1: Alligator mississipiensis (2.5 Gb genome), the American alligator, for high quality draft genomic sequence (approx. 6x) plus ESTs. 2. Reptile 2: Chrysemys picta (2.6 Gb genome), the painted turtle, for high quality draft genomic sequence (approx. 6x) plus ESTs. 3. Amphibian: Ambystoma mexicanum (>32 Gb genome), the Mexican axolotl, a urodele, for 100,000 ESTs only. 4. Sarcopterygian fish 1: Latimeria chalumnae (2.75 Gb genome), the African coelacanth, for high quality draft genomic sequence (approx. 6x) plus ESTs. 5. Sarcopterygian fish 2: Neoceratodus forsteri (>30 Gb genome), the Australian lungfish, for 100,000 ESTs only. 6. Basal actinopterygian fish: Lepisosteus oculatus (1.4 Gb genome), the spotted gar, for high quality draft genomic sequence (approx. 6x) plus ESTs. 7. Cartliaginous fish: Raja erinacea (3.3 Gb genome), the little skate, for high quality draft genomic sequence (approx. 6x) plus ESTs. 8. Jawless fish: Eptatretus burgeri (2.5-3.0 Gb genome), the Japanese Hagfish, for high quality draft genomic sequence (approx. 6x) plus ESTs. 9. Basal chordate: Branchiostoma lanceolatum (0.6 Gb genome), the European lancelet or amphioxus, for high quality draft genomic sequence (approx. 6x) plus 50,000 ESTs
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